10.3748/wjg.v19.i12.1962 99 TangJ
The proportion of memory cytotoxic T-cells (CD8 + CD45 Ro + ) ( Figure 6D ) relative to total CD8 + rose to a maximum until 4 h pi , before slightly decreasing to a minimum at 48 h pi and returning to the initial level at 72 h pi
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The nanosystem eradicated 67% of the 4T1 tumors and significantly suppressed lung metastasis of the 4T1 tumor cells without inducing obvious body weight change or histopathological organ damage of the tumor-bearing mice (Feng et al., 2019)
However, in IRI, the dual nature of lactate, providing a protective effect through energy supply while simultaneously promoting ferroptotic damage, poses significant challenges for its clinical application